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Article

Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma.

Hepatology (Baltimore, Md.) - 1 Jul 2018

Zheng Hongping, Pomyen Yotsawat, Hernandez Maria Olga, Li Caiyi, Livak Ferenc, Tang Wei, Dang Hien, Greten Tim F, Davis Jeremy L, Zhao Yongmei, Mehta Monika, Levin Yelena, Shetty Jyoti, Tran Bao, Budhu Anuradha, Wang Xin Wei

Abstract excerpt

Intratumor molecular heterogeneity of hepatocellular carcinoma is partly attributed to the presence of hepatic cancer stem cells (CSCs). Different CSC populations defined by various cell surface markers may contain different oncogenic drivers, posing a challenge in defining molecularly targeted therapeutics. We combined transcriptomic and functional analyses of hepatocellular carcinoma cells at the single-cell...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29315726
DOI: 10.1002/hep.29778
PMCID: PMC6033650

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