Article
Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto's thyroiditis.
Nature genetics - 1 Aug 2026
Bujnis Melissa N, Sterenborg Rosalie B T M, Li Yong, Åsvold Bjørn Olav, Brčić Luka, Boraska Perica Vesna, Babbar Anav, Denny Joshua C, Fritsche Lars G, Kanai Masahiro, Konrade Ilze, Leese Graham, Marouli Eirini, Metspalu Andres, Moksnes Marta R, Mukherjee Bhramar, Okada Yukinori, Palmer Colin N A, Papadopoulou Areti, Peculis Raitis, Rovite Vita, Sauer Peter J, Soto-Pedre Enrique, Srinivasan Sundararajan, Steinbrenner Inga, Teder-Laving Maris, Wang Bin, Weihs Antoine, Zeng Chenjie, Zhou Jin, Song XiCheng, Jorde Lynn B, Medici Marco, Teumer Alexander
Abstract excerpt
Autoimmune hypothyroidism (Hashimoto's thyroiditis) is common and has a strong genetic component. Here we performed multi-ancestry genome-wide association meta-analyses encompassing 48,694 Hashimoto's thyroiditis cases, using a precise case definition, and 1,044,134 controls. We identified 155 significant (P < 5 × 10-8) independent genetic associations, of which 45 variants and 19 loci were not previously...
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