Predicting immune-related thyroiditis using polygenic risk scores in patients with advanced melanoma.

doi:10.1136/jitc-2026-015413

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Article

Predicting immune-related thyroiditis using polygenic risk scores in patients with advanced melanoma.

Journal for immunotherapy of cancer - 19 Jun 2026

Tarhini Ahmad A, Khaksar Mohammad Ali, Chen Zhihua, Lee Sandra J, Stephen Hodi F, Li Tingyi, Yoder Sean J, Streicher Howard, Sondak Vernon K, Kirkwood John M, Wang Xuefeng, Kanetsky Peter A

Abstract excerpt

BACKGROUND: Inherited genetic variation may impact patient response and risk of toxicity following immune checkpoint inhibitor (ICI) therapy. METHODS: We conducted an agnostic genome-wide analysis study for inherited genetic variants that may predict thyroiditis in patients with melanoma treated with ipilimumab and investigated Polygenic Risk Scores (PRSs) previously reported to be associated with thyroid...

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PMID: 42320988
DOI: 10.1136/jitc-2026-015413
PMCID: PMC13289257

Genes

CNOT6L
CXCL13

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