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Article

Immunogenetic modulation of endothelial inflammation by the LIPG -384A/C promoter variant influences COVID-19 severity.

Frontiers in immunology - 1 Jan 2026

Singh HariOm, Nair Aishwarya, Bhattacharya Meenakshi, Tripathi Gaurav, Nishat Shamama, AlAsmari Abdullah F, Ali Nemat

Abstract excerpt

Background: Severe COVID-19 is characterized by dysregulated host immune responses and immune-mediated endothelial injury, culminating in microvascular dysfunction and systemic inflammation. Endothelial lipase (EL), encoded by the LIPG gene, regulates endothelial lipid metabolism and inflammatory signaling pathways that influence immune-endothelial interactions. Despite its relevance to vascular immunopathology,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42317324
DOI: 10.3389/fimmu.2026.1785738
PMCID: PMC13273450

Genes

LIPG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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