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Translating osteoarthritis genetics research: challenging times ahead.

Trends in molecular medicine - 1 Mar 2022

Loughlin John

Abstract excerpt

The ultimate goal of molecular genetic studies of human diseases is to translate the discoveries for patient benefit. For diseases that lack licensed disease-modifying therapeutics, such as osteoarthritis (OA), the need is acute. OA is polygenic and affects older individuals, with a recent genome-wide study of over 800 000 individuals adding 52 novel association signals to those already reported on for this...

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PMID: 35033441
DOI: 10.1016/j.molmed.2021.12.007

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