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Patient-derived glioblastoma cultures preserve respiration phenotypes during ex vivo maintenance and show sex-associated differences in migration.

Acta neuropathologica communications - 18 Jun 2026

Matschke Veronika, Glover Philip, Lucaciu Robert, Pickmann David, Scholz Martin, Theiss Carsten, Hoffmann Daniel, Matschke Johann

Abstract excerpt

Glioblastoma (GBM) is a highly heterogeneous, invasive brain tumor with profound metabolic plasticity. Patient-derived cultures provide valuable preclinical models, yet the stability and clinical relevance of their metabolic phenotypes during ex vivo maintenance remain unclear. Here, we performed longitudinal functional profiling of mitochondrial respiration, substrate utilization, and migration in primary...

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PMID: 42316281
DOI: 10.1186/s40478-026-02349-0
PMCID: PMC13282857

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