Article
Efficient Mitochondrial Glutamine Targeting Prevails Over Glioblastoma Metabolic Plasticity.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2017
Oizel Kristell, Chauvin Cynthia, Oliver Lisa, Gratas Catherine, Geraldo Fanny, Jarry Ulrich, Scotet Emmanuel, Rabe Marion, Alves-Guerra Marie-Clotilde, Teusan Raluca, Gautier Fabien, Loussouarn Delphine, Compan Vincent, Martinou Jean-Claude, Vallette François M, Pecqueur Claire
Abstract excerpt
Purpose: Glioblastoma (GBM) is the most common and malignant form of primary human brain tumor in adults, with an average survival at diagnosis of 18 months. Metabolism is a new attractive therapeutic target in cancer; however, little is known about metabolic heterogeneity and plasticity within GBM tumors. We therefore aimed to investigate metabolic phenotyping of primary cultures in the context of molecular...
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