BDNF rs6265 polymorphism is not associated with the occurrence of overactive bladder and its response to intradetrusor injection of botulinum neurotoxin type A in female patients.

doi:10.1038/s41598-026-58792-5

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BDNF rs6265 polymorphism is not associated with the occurrence of overactive bladder and its response to intradetrusor injection of botulinum neurotoxin type A in female patients.

Scientific reports - 18 Jun 2026

Ciećwież Sylwester Michał, Lewandowska Klaudyna, Boroń Agnieszka, Kotlęga Dariusz, Kociszewski Jacek, Grocholewicz Katarzyna, Clark Jeremy S, Ciechanowicz Andrzej

Abstract excerpt

Reports suggest increased urinary excretion of Brain-Derived Neurotrophic Factor in patients with Overactive Bladder (OAB). The rs6265 (c.196G > A, p.Val66Met) polymorphism in the BDNF gene was previously associated with impaired secretion of this neurotrophin. The aims of the present study were to analyze the possible association of the BDNF: rs6265 polymorphism with OAB risk and with the response to a single...

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Topics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Urinary Bladder, Overactive

Female

Brain-Derived Neurotrophic Factor

Botulinum Toxins, Type A

Polymorphism, Single Nucleotide

Middle Aged

Adult

Genotype

Case-Control Studies

Genetic Predisposition to Disease

Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 42315574
DOI: 10.1038/s41598-026-58792-5
PMCID: PMC13554184

Genes

BDNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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