Article
Association analysis of ADRB3:rs4994 with urodynamic outcome, six months after a single intra-detrusor injection of botulinum toxin, in women with overactive bladder.
Pharmacological reports : PR - 1 Dec 2024
Ciećwież Sylwester, Lewandowska Klaudyna, Szylińska Aleksandra, Boroń Agnieszka, Kotlęga Dariusz, Kociszewski Jacek, Brodowska Agnieszka, Clark Jeremy S C, Ciechanowicz Andrzej
Abstract excerpt
BACKGROUND: Intra-detrusor injection of botulinum neurotoxin type A (BoNT/A) is recommended as a possible treatment for patients with overactive bladder (OAB) in whom first-line therapies have failed. The c.190T > C (rs4994) polymorphism in the gene encoding the beta-3 adrenergic receptor (ADRB3) has been suggested to be associated with predisposition to OAB or with response to OAB treatment via a cholinergic...
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