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Article

IHC p53 Performance in NordiQC: Recalibration of IHC Assays is Needed.

Applied immunohistochemistry & molecular morphology : AIMM - 1 May 2026

Anderson Kristi Bøgh, Nielsen Søren, Røge Rasmus

Abstract excerpt

The TP53 gene is the most frequently mutated gene in human cancers, with alterations occurring in ∼50% of all malignancies. When properly optimized, p53 immunohistochemistry (IHC) can serve as a reliable surrogate for detecting TP53 mutations. However, many laboratories struggle to identify p53 IHC reaction patterns beyond overexpression, particularly the absence, cytoplasmic, and wild-type patterns. As the...

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Calibration
TP53 gene
Immunohistochemistry
Mutation
Neoplasms
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41851024
DOI: 10.1097/PAI.0000000000001314
PMCID: PMC13143367

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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