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Article

New Opportunities for Targeting the Androgen Receptor in Prostate Cancer.

Cold Spring Harbor perspectives in medicine - 3 Dec 2018

Centenera Margaret M, Selth Luke A, Ebrahimie Esmaeil, Butler Lisa M, Tilley Wayne D

Abstract excerpt

Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29530945
DOI: 10.1101/cshperspect.a030478
PMCID: PMC6280715

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Androgen Receptor Signaling in Prostate Cancer and Therapeutic StrategiesSemantic proximity Read ↗

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