Article
Effect of methylation on genome mutability in cattle.
Genetics, selection, evolution : GSE - 17 Jun 2026
Fouéré Corentin, Costes Valentin, Hozé Chris, Besnard Florian, Costa Monteiro Moreira Gabriel, Fritz Sébastien, Kiefer Hélène, Sanchez Marie-Pierre, Boichard Didier, Boussaha Mekki
Abstract excerpt
BACKGROUND: Germline de novo mutations (DNMs) are rare events in mammals, typically occurring only a few dozen times per generation. These mutations are not entirely random; several factors are known to influence their rate, including DNA methylation. In this study, we leveraged the unique population structure of cattle with a few ancestors having a large contribution to the current gene pool, along with...
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