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Article

Mutant alleles differentially shape fitness and other complex traits in cattle.

Communications biology - 2 Dec 2021

Xiang Ruidong, Breen Ed J, Bolormaa Sunduimijid, Jagt Christy J Vander, Chamberlain Amanda J, Macleod Iona M, Goddard Michael E

Abstract excerpt

Mutant alleles (MAs) that have been classically recognised have large effects on phenotype and tend to be deleterious to traits and fitness. Is this the case for mutations with small effects? We infer MAs for 8 million sequence variants in 113k cattle and quantify the effects of MA on 37 complex traits. Heterozygosity for variants at genomic sites conserved across 100 vertebrate species increase fertility,...

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Identifiers

PMID: 34857886
DOI: 10.1038/s42003-021-02874-9
PMCID: PMC8640064

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