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Article

Punctuated evolution of canonical genomic aberrations in uveal melanoma.

Nature communications - 9 Jan 2018

Field Matthew G, Durante Michael A, Anbunathan Hima, Cai Louis Z, Decatur Christina L, Bowcock Anne M, Kurtenbach Stefan, Harbour J William

Abstract excerpt

Cancer is thought to arise through the accumulation of genomic aberrations evolving under Darwinian selection. However, it remains unclear when the aberrations associated with metastasis emerge during tumor evolution. Uveal melanoma (UM) is the most common primary eye cancer and frequently leads to metastatic death, which is strongly linked to BAP1 mutations. Accordingly, UM is ideally suited for studying the...

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Share to DNA Copy Number Variations
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29317634
DOI: 10.1038/s41467-017-02428-w
PMCID: PMC5760704

Genes

BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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