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Article

Antagonism of RNA silencing in the yellow fever mosquito, Aedes aegypti, by the nsP2 protein of the prototype alphavirus.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2026

Gupta Adarsh K, Wiley Michael R, Myles Kevin M

Abstract excerpt

Alphaviruses establish persistent infections in mosquito vectors despite robust antiviral RNA interference (RNAi) pathways, suggesting that they employ mechanisms to counteract host immunity. We demonstrate that the nsP2 protein of Sindbis virus (SINV), the prototype alphavirus, functions as a viral suppressor of RNA silencing in Aedes aegypti mosquitoes. Using a SINV mutant (2V) that prevents cleavage at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41662525
DOI: 10.1073/pnas.2521417123
PMCID: PMC12913014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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