Subclass-Specific Impact of β1-Adrenergic Receptor Autoantibodies and Phenotype-Specific Interaction With β-Blockers in a Contemporary Population With Heart Failure.

doi:10.1161/JAHA.125.047402

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Article

Subclass-Specific Impact of β1-Adrenergic Receptor Autoantibodies and Phenotype-Specific Interaction With β-Blockers in a Contemporary Population With Heart Failure.

Journal of the American Heart Association - 16 Jun 2026

Kawai Akane, Nagatomo Yuji, Iwashita Midori, Morita Nao, Naito Ayami, Nakazawa Ryota, Taruoka Akira, Takefuji Asako, Yasuda Risako, Konishi Takao, Ikegami Yukinori, Toya Takumi, Masaki Nobuyuki, Ido Yasuo, Baba Akiyasu, Yoshikawa Tsutomu, Tang W H Wilson, Adachi Takeshi

Abstract excerpt

BACKGROUND: The clinical significance of β1AR-AAb (β1-adrenergic receptor autoantibody) subclasses, particularly IgG3 (immunoglobulin G subclass 3), in contemporary populations with HF (heart failure) remain unclear, especially in relation to β-blocker therapy and HF phenotype. METHODS: In this single-center prospective cohort study, we enrolled 408 consecutive patients hospitalized for acute decompensated HF....

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PMID: 42294765
DOI: 10.1161/JAHA.125.047402

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