Article
Fcgamma-receptor IIa polymorphism and the role of immunoadsorption in cardiac dysfunction in patients with dilated cardiomyopathy.
Clinical pharmacology and therapeutics - 1 Apr 2010
Staudt A, Herda L R, Trimpert C, Lubenow L, Landsberger M, Dörr M, Hummel A, Eckerle L G, Beug D, Müller C, Hoffmann W, Weitmann K, Klingel K, Kandolf R, Kroemer H K, Greinacher A, Felix S B
Abstract excerpt
In patients with dilated cardiomyopathy (DCM), cardiac autoantibodies are able to bind with their Fab fragment to epitopes on cardiomyocytes, but thereafter they crosslink through their Fc fragment to cardiac Fc(gamma)-receptor IIa. Polymorphic variability of the Fc(gamma)-receptor IIa is associa...
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