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Article

Distinct age-related effects of homologous recombination deficiency on genomic profiling and treatment efficacy in gastric cancer.

Journal of gastroenterology - 1 Oct 2025

Maki Yoshie, Kono Yoshiyasu, Ozato Toshiki, Yamamoto Hideki, Hirasawa Akira, Ennishi Daisuke, Tomida Shuta, Toyooka Shinichi, Hamada Kenta, Iwamuro Masaya, Kawano Seiji, Otsuka Motoyuki

Abstract excerpt

BACKGROUND: The incidence of gastric cancer among younger patients is increasing globally, with growing attention being paid to the role of homologous recombination deficiency (HRD). However, the effect of HRD on treatment outcomes and prognosis in this population remains unclear. METHODS: We analyzed clinical and genomic data from the Center for Cancer Genomics and Advanced Therapeutics database. Younger...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40514520
DOI: 10.1007/s00535-025-02267-3
PMCID: PMC12450818

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