Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer.

doi:10.1056/NEJMoa2211807

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Article

Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer.

The New England journal of medicine - 30 Mar 2023

Usui Yoshiaki, Taniyama Yukari, Endo Mikiko, Koyanagi Yuriko N, Kasugai Yumiko, Oze Isao, Ito Hidemi, Imoto Issei, Tanaka Tsutomu, Tajika Masahiro, Niwa Yasumasa, Iwasaki Yusuke, Aoi Tomomi, Hakozaki Nozomi, Takata Sadaaki, Suzuki Kunihiko, Terao Chikashi, Hatakeyama Masanori, Hirata Makoto, Sugano Kokichi, Yoshida Teruhiko, Kamatani Yoichiro, Nakagawa Hidewaki, Matsuda Koichi, Murakami Yoshinori, Spurdle Amanda B, Matsuo Keitaro, Momozawa Yukihide

Abstract excerpt

BACKGROUND: Helicobacter pylori infection is a well-known risk factor for gastric cancer. However, the contribution of germline pathogenic variants in cancer-predisposing genes and their effect, when combined with H. pylori infection, on the risk of gastric cancer has not been widely evaluated. METHODS: We evaluated the association between germline pathogenic variants in 27 cancer-predisposing genes and the risk...

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PMID: 36988593
DOI: 10.1056/NEJMoa2211807

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