Article
Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2011
Ding Hongliu, Sarokhan Alison K, Roderick Sarah S, Bakshi Rachit, Maher Nancy E, Ashourian Paymon, Kan Caroline G, Chang Sunny, Santarlasci Andrea, Swords Kyleen E, Ravina Bernard M, Hayes Michael T, Sohur U Shivraj, Wills Anne-Marie, Flaherty Alice W, Unni Vivek K, Hung Albert Y, Selkoe Dennis J, Schwarzschild Michael A, Schlossmacher Michael G, Sudarsky Lewis R, Growdon John H, Ivinson Adrian J, Hyman Bradley T, Scherzer Clemens R
Abstract excerpt
BACKGROUND: Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies. METHODS: We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard...
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