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Potential Association of BRAF and PIK3CA Copy Number Alterations with Long-Term Survival in IDH-Wildtype Glioblastoma: A Pilot Study.

International journal of molecular sciences - 22 May 2026

Tomoszková Silvia, Drozdková Denisa, Vaculová Jana, Delongová Patricie, Palička Martin, Škarda Jozef, Lipina Radim

Abstract excerpt

IDH-wildtype glioblastoma remains the most aggressive primary brain tumor, with a median overall survival (OS) of 14-16 months despite maximal treatment. A small subset of patients, however, survive beyond 30 months, suggesting distinct underlying biological features. The aim of this pilot study was to explore whether selected molecular alterations detectable by FISH show differing distribution patterns between...

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Brain Neoplasms
Class I Phosphatidylinositol 3-Kinases
DNA Copy Number Variations
DNA Modification Methylases
DNA Repair Enzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

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Open in PubMed Open full text

Identifiers

PMID: 42278221
DOI: 10.3390/ijms27114688
PMCID: PMC13256860

Genes

BRAF
PIK3CA
EGFR
MGMT
ATRX
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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