Whole-Genome Sequencing and Phenotypic Drug Susceptibility Testing of Bedaquilin, Delamanid, Pretomanid, and Linezolid in Drug-Resistant Mycobacterium tuberculosis from a Single Institute in South Korea.

doi:10.3390/pathogens15030320

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Whole-Genome Sequencing and Phenotypic Drug Susceptibility Testing of Bedaquilin, Delamanid, Pretomanid, and Linezolid in Drug-Resistant Mycobacterium tuberculosis from a Single Institute in South Korea.

Pathogens (Basel, Switzerland) - 16 Mar 2026

Choi Hyun-Woo, Kang Yoo-Ree, Son Eun-Soon, Choi Kyungsik, Cho Myungsun, Kim Young Jin, Lee Seo A, Lee Jin Young, Kim Jee Hey, Kang Seon Joo, Kee Seung-Jung, Lee Jong Seok, Lee Hee Joo

Abstract excerpt

Multidrug-resistant tuberculosis is a major global health concern. Newer agents, including bedaquiline (BDQ), delamanid (DLM), pretomanid (PMD), and linezolid (LZD), are essential for treatment; however, the resistance mechanisms of these drugs remain poorly understood in South Korea. This study aimed to investigate correlations between phenotypic and genotypic resistance to these drugs using 49 clinical...

Topics

Microbial Sensitivity Tests
Republic of Korea
Mycobacterium tuberculosis
Whole Genome Sequencing
Antitubercular Agents
Humans
Tuberculosis, Multidrug-Resistant
Drug Resistance, Multiple, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Mutation

Linezolid

Nitroimidazoles

Genotype

Oxazoles

Source

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PMID: 41901773
DOI: 10.3390/pathogens15030320
PMCID: PMC13028822

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