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Article

Convergent evolution of the N156K mutation in A(H1N1)pdm09 hemagglutinin contributes to antigenic drift and cluster transition.

Emerging microbes & infections - 1 Dec 2026

Tian Yabin, Jiang Deyun, Ma Wentai, Nie Jianhui, Li Qianqian, Zhao Chenyan, Xu Sihong, Huang Weijin, Wang Youchun

Abstract excerpt

The continuous antigenic evolution of influenza A(H1N1)pdm09 poses a persistent challenge to vaccine efficacy. While recent viral lineages have diverged significantly from ancestral strains, the precise molecular determinants driving the latest antigenic cluster transitions remain incompletely characterized. Here, using the broadly neutralizing monoclonal antibody 32D6 as a molecular probe, we identified a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hemagglutinin Glycoproteins, Influenza Virus

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Share to Influenza A Virus, H1N1 Subtype

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Source

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Identifiers

PMID: 42267384
DOI: 10.1080/22221751.2026.2687185
PMCID: PMC13288905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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