Identification of circadian rhythm-related genes in colorectal cancer by integrating bioinformatics and multi-omics mendelian randomization.

doi:10.1007/s00210-026-05187-y

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Article

Identification of circadian rhythm-related genes in colorectal cancer by integrating bioinformatics and multi-omics mendelian randomization.

Naunyn-Schmiedeberg's archives of pharmacology - 1 May 2026

Shen Zhengjie, Tao Minxian, Qin Yin, Tang Wenkai, Yuan Yuan, Gu Wenzhe

Abstract excerpt

Circadian rhythm disorders are epidemiologically linked to colorectal cancer (CRC), but causal relationships and molecular mechanisms remain unclear. We applied a multi-omics Mendelian Randomization (SMR) framework to assess the causal effects of circadian rhythm-related genes on CRC. Instrumental variables were derived from blood-based QTLs for methylation (mQTL), expression (eQTL), and protein levels (pQTL),...

Topics

Humans
Colorectal Neoplasms
Circadian Rhythm
Quantitative Trait Loci
Multiomics
Mendelian Randomization Analysis
Computational Biology
Genome-Wide Association Study
Genetic Predisposition to Disease
DNA Methylation
Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 41801343
DOI: 10.1007/s00210-026-05187-y
PMCID: PMC13269306

Genes

GRHPR
NAF1
UVSSA
ZNF365

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