Basal Cells Contribute to Pulmonary Fibrosis via SP1-Mediated Senescence-Associated Secretory Phenotype.

Abstract excerpt

Idiopathic pulmonary fibrosis is a progressive interstitial lung disease with limited treatment options and poor prognosis. Increasing evidence suggests that airway epithelial remodeling contributes to disease pathogenesis, yet the role of basal cells remains incompletely understood. This study aimed to determine whether basal cells participate in pulmonary fibrosis through a senescence-associated secretory...

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