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Article

Delivery of extracellular vesicle-associated microRNA-146a regulates human monocyte phenotype and function.

Journal of immunology (Baltimore, Md. : 1950) - 4 Aug 2026

Mentkowski Kyle I, Tarvirdizadeh Touba, Pandey Rohan, Schiffmacher Paul J, Hough Sara, Eagler Lisa A, Sim Fraser J, Reynolds Jessica, Lang Jennifer K

Abstract excerpt

CCR2+ monocytes are recruited to sites of acute myocardial injury, where they play a critical role in clearing necrotic debris and replenishing the depleted resident macrophage population. Although this response is necessary for early tissue repair, prolonged activation of inflammatory pathways and persistent recruitment of CCR2+ monocytes have been associated with accelerated ventricular remodeling and adverse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42568044
DOI: 10.1093/jimmun/vkag226

Genes

CCR2
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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