Article
Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2026
Farombi Temitope, Azzi Tiago, Legaz Agustina, Aguillón David, Avila-Funes José Alberto, Behrens Maria Isabel, Bruno Martín, Cardona Juan Felipe, Custodio Nilton, Delgado Carolina, Pina-Escudero Stefanie, Galofre Maria Del Pilar Garavito, Maito Marcelo, Magrath-Guimet Nahuel, Miller Justin B, Matallana Diana, de Oliveira Maira Okada, Rocatti Guido, Resende Elisa de Paula França, Slachevsky Andrea, Takada Leonel, Wen Olivia, Zapata-Restrepo Lina M, Lawlor Brian, Yaffe Kristine, Hu Kun, Miller Bruce, Possin Katherine, Yokoyama Jennifer S, Fittipaldi Sol, García Adolfo M, Larzabal Hernan Hernandez, Santamaria-Garcia Hernando, Tagliazzuchi Enzo, Duran-Aniotz Claudia, Ibanez Agustin, Migeot Joaquin
Abstract excerpt
INTRODUCTION: Adverse social conditions across the life course influence brain aging and dementia, yet their compounded impact on clinical phenotypes remains underexplored, particularly in Latin America, where social inequality and dementia burden are high. METHODS: We studied 3941 individuals from six Latin American countries, including cognitively unimpaired controls (CU), Alzheimer's disease (AD), and...
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