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Article

Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility.

Human reproduction (Oxford, England) - 1 Dec 2006

Lee Han-Chul, Jeong Yu-Mi, Lee Sook Hwan, Cha Kwang Yul, Song Seung-Hun, Kim Nam Keun, Lee Kyo Won, Lee Suman

Abstract excerpt

BACKGROUND: Three typical folate metabolism enzymes-i.e. methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS) and MS reductase (MTRR) in the folate cycle-play a critical role in DNA synthesis and methylation reactions. We evaluated whether polymorphisms of these three enzymes are associated with non-obstructive male infertility. METHOD: Three hundred and sixty patients with non-obstructive...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferredoxin-NADP Reductase

Share to Folic Acid

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 16861746
DOI: 10.1093/humrep/del280

Genes

MTHFR
MTRR
OAT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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