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Article

Absence of co-occurrence between HER2 amplification and dMMR/MSI in a large multicentric colorectal cancer cohort.

Scientific reports - 5 Jun 2026

Gandini Annalice, Tosi Federica, Carmisciano Luca, Grillo Federica, Mastracci Luca, Puglisi Silvia, Pirrone Chiara, Nardin Simone, Martelli Valentino, Pastorino Alessandro, Mauri Gianluca, Amatu Alessio, Bonazzina Erica, Bencardino Katia, Piscazzi Daniele, Siena Salvatore, Aquilano Maria Costanza, Sciallero Stefania, Sartore-Bianchi Andrea, Puccini Alberto

Abstract excerpt

Mismatch repair deficiency (dMMR)/Microsatellite instability (MSI) plays a central role in colorectal cancer (CRC) as a predictive and prognostic biomarker and as a "red flag" for diagnosis of Lynch Syndrome (LS). HER2 is emerging as a therapeutic target and clinical trials are ongoing. Several reports suggested that HER2 amplification could be mutually exclusive with dMMR/MSI, which is mostly associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42249044
DOI: 10.1038/s41598-026-56380-1
PMCID: PMC13490487

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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