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Article

Integrating genetic and lifestyle determinants in a risk prediction model for esophageal squamous cell carcinoma in Taiwan.

Scientific reports - 5 Jun 2026

Chung Chen-Shuan, Chen Yi-Hsun, Hsu Ming-Hung, Yu Chen-Huan, Wang Wen-Lun, Wang Hsiu-Po, Wu Ming-Shiang, Lee Chien-Hung, Chen Che-Hong, Wu I-Chen

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) in East Asia is markedly male predominant, strongly associated with genetic susceptibility and modifiable lifestyle exposures. We developed and validated a risk appraisal model for ESCC by integrating genetic polymorphisms of two key alcohol-metabolizing enzymes-ADH1B and ALDH2-with major carcinogenic exposures from alcohol, tobacco, and betel quid among men. Genetic and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42248990
DOI: 10.1038/s41598-026-55075-x
PMCID: PMC13482638

Genes

ADH1B
ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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