Multilevel pathways to esophageal cancer: Population attributable risks of modifiable exposures, surrogate blood biomarkers, and genetic susceptibility, and the mediation effects based on a 10-year prospective cohort study.

Abstract excerpt

Numerous studies have elucidated the contributions of modifiable risk factors, blood-based biomarkers, and genetic variants to the etiology of esophageal cancer (EC). However, it lacks systematic evaluation of their contribution to EC risk in prospective cohorts of the Chinese population. We prospectively examined the association between 10 modifiable risk factors, 54 blood biomarkers, an established 11-locus...

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