Article
Inclusion of a gene-environment interaction between alcohol consumption and the aldehyde dehydrogenase 2 genotype in a risk prediction model for upper aerodigestive tract cancer in Japanese men.
Cancer science - 1 Oct 2020
Iwasaki Motoki, Budhathoki Sanjeev, Yamaji Taiki, Tanaka-Mizuno Sachiko, Kuchiba Aya, Sawada Norie, Goto Atsushi, Shimazu Taichi, Inoue Manami, Tsugane Shoichiro
Abstract excerpt
The well-known gene-environment interaction between alcohol consumption and aldehyde dehydrogenase 2 (ALDH2) genotype in upper aerodigestive tract cancer risk may improve our ability to identify high-risk subjects. Here, we developed and validated risk prediction models for this cancer in Japanese men and evaluated whether adding the gene-environment interaction to the model improved the predictive performance....
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