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Article

Selective vulnerability of dopaminergic neurons in Parkinson's disease connects PRKN and differential expression of CHCHD2 and GPNMB.

Cell death & disease - 5 Jun 2026

Vulinovic Franca, Hach Arian, Landoulsi Zied, Tanzer Kerstin, Alvarez-Fischer Daniel, Seibler Philip, Klein Christine, May Patrick, Rakovic Aleksandar

Abstract excerpt

The mechanism(s) causing selective vulnerability of dopaminergic neurons in Parkinson's disease (PD) remain largely elusive. To improve our understanding of mitochondrial involvement and related pathways suggested to play a role in this selective vulnerability, we used tyrosine hydroxylase (TH)-mCherry reporter-induced pluripotent stem cells generated by CRISPR/Cas9. We sorted neurons into pure TH-positive and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42248828
DOI: 10.1038/s41419-026-08926-4
PMCID: PMC13241505

Genes

TH
PRKN
CHCHD2
GPNMB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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