Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exercise Training Reveals Inflexibility of the Diaphragm in an Animal Model of Patients With Obesity-Driven Heart Failure With a Preserved Ejection Fraction.

Journal of the American Heart Association - 24 Oct 2017

Bowen T Scott, Brauer Dominic, Rolim Natale P L, Bækkerud Fredrik H, Kricke Angela, Ormbostad Berre Anne-Marie, Fischer Tina, Linke Axel, da Silva Gustavo Justo, Wisloff Ulrik, Adams Volker

Abstract excerpt

BACKGROUND: Respiratory muscle weakness contributes to exercise intolerance in patients with heart failure with a preserved ejection fraction (HFpEF)-a condition characterized by multiple comorbidities with few proven treatments. We aimed, therefore, to provide novel insight into the underlying diaphragmatic alterations that occur in HFpEF by using an obese cardiometabolic rat model and further assessed whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diaphragm
Share to Exercise Tolerance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mitochondria, Muscle

Share to Muscle Weakness

Share to Rats, Zucker

Share to Stroke Volume

Share to Tripartite Motif Proteins

Share to Ventricular Function, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 29066440
DOI: 10.1161/JAHA.117.006416
PMCID: PMC5721851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exercise Training Reveals Inflexibility of the Diaphragm in an Animal Model of Patients With Obesity-Driven Heart Failure With a Preserved Ejection Fraction.PMID 29066440Read ↗

Cardiometabolic Phenotype in HFpEF: Insights from Murine ModelsSemantic proximity Read ↗

Aerobic exercise partially improves the skeletal muscle phenotype in a model of heart failure with preserved ejection fraction in male mice.Semantic proximity Read ↗

Cardiac and respiratory muscle responses to dietary N-acetylcysteine in rats consuming a high-saturated fat, high-sucrose dietSemantic proximity Read ↗

A novel Sarcopenic Obesity Rat Model Based on Ageing and High-fat DietSemantic proximity Read ↗

Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse modelSemantic proximity Read ↗

Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction.Semantic proximity Read ↗

A matter of food and substrain: obesogenic diets induce differential severity of cardiac remodeling and diastolic dysfunction in C57Bl/6J and C57Bl/6N substrainsSemantic proximity Read ↗

Obesity/cardiometabolic phenotype of heart failure with preserved ejection fraction: mechanisms to recent trials.Semantic proximity Read ↗

Sex Differences in Skeletal Muscle Pathology in Patients With Heart Failure and Reduced Ejection FractionSemantic proximity Read ↗

Targeting Metabolic Dysfunction and Inflammation with Sotagliflozin Reverses Diastolic Dysfunction in Experimental HFpEFSemantic proximity Read ↗

Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice.Semantic proximity Read ↗

Therapeutic potential of Relaxin-2 in Heart Failure with preserved Ejection Fraction (HFpEF)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.