Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Patterns of structural variants within TP53 introns and relocation of the TP53 promoter: a commentary†.

The Journal of pathology - 1 Jun 2024

Beird Hannah C, Lin Dimitri, Lazar Alexander J, Futreal P Andrew

Abstract excerpt

Gene disruption from double-strand DNA breaks within introns is a mechanism of inactivating the tumor suppressor TP53. This occurs more frequently in osteosarcoma and biliary adenocarcinoma compared with other cancer types. The patterns of intron breakpoints within TP53 do not correlate with prevalence, intron length, or overall genome-wide levels of rearrangements. Therefore, these breakpoints appear to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Introns
Share to Mutation
Share to Osteosarcoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 38482738
DOI: 10.1002/path.6270

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patterns of structural variants within TP53 introns and relocation of the TP53 promoter: a commentary†.PMID 38482738Read ↗

Disruption of the TP53 locus in osteosarcoma leads to TP53 promoter gene fusions and restoration of parts of the TP53 signalling pathway.Semantic proximity Read ↗

Recommendations for analyzing and reporting TP53 gene variants in the high-throughput sequencing era.Semantic proximity Read ↗

Mutational Landscape of TP53 Across Cancer TypesSemantic proximity Read ↗

Tumor patterns and cancer risk in carriers of TP53 exonic germline variants that alter mRNA splicing.Semantic proximity Read ↗

SEOM clinical guideline on heritable TP53-related cancer syndrome (2022).Semantic proximity Read ↗

Tumor Patterns and Cancer Risk in Carriers of <i>TP53</i> exonic Germline Variants that alter mRNA SplicingSemantic proximity Read ↗

Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene.Semantic proximity Read ↗

<i>TP53</i> minigene analysis of 161 sequence changes provides evidence for role of spatial constraint and regulatory elements on variant-induced splicing impactSemantic proximity Read ↗

Analysis of the Li-Fraumeni Spectrum Based on an International Germline TP53 Variant Data Set: An International Agency for Research on Cancer TP53 Database Analysis.Semantic proximity Read ↗

<i>In-Silico</i> Characterization of <i>TP53</i> Splice Mutations in Somatic and Germline TumoursSemantic proximity Read ↗

Variation characteristics and clinical significance of TP53 in patients with myeloid neoplasms.Semantic proximity Read ↗

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.