Article
Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression.
Cell - 9 Jul 2020
Chen Yi-Ju, Roumeliotis Theodoros I, Chang Ya-Hsuan, Chen Ching-Tai, Han Chia-Li, Lin Miao-Hsia, Chen Huei-Wen, Chang Gee-Chen, Chang Yih-Leong, Wu Chen-Tu, Lin Mong-Wei, Hsieh Min-Shu, Wang Yu-Tai, Chen Yet-Ran, Jonassen Inge, Ghavidel Fatemeh Zamanzad, Lin Ze-Shiang, Lin Kuen-Tyng, Chen Ching-Wen, Sheu Pei-Yuan, Hung Chen-Ting, Huang Ke-Chieh, Yang Hao-Chin, Lin Pei-Yi, Yen Ta-Chi, Lin Yi-Wei, Wang Jen-Hung, Raghav Lovely, Lin Chien-Yu, Chen Yan-Si, Wu Pei-Shan, Lai Chi-Ting, Weng Shao-Hsing, Su Kang-Yi, Chang Wei-Hung, Tsai Pang-Yan, Robles Ana I, Rodriguez Henry, Hsiao Yi-Jing, Chang Wen-Hsin, Sung Ting-Yi, Chen Jin-Shing, Yu Sung-Liang, Choudhary Jyoti S, Chen Hsuan-Yu, Yang Pan-Chyr, Chen Yu-Ju
Abstract excerpt
Lung cancer in East Asia is characterized by a high percentage of never-smokers, early onset and predominant EGFR mutations. To illuminate the molecular phenotype of this demographically distinct disease, we performed a deep comprehensive proteogenomic study on a prospectively collected cohort in Taiwan, representing early stage, predominantly female, non-smoking lung adenocarcinoma. Integrated genomic,...
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