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Article

Blood circulating C228T TERT gene promoter mutation is an independent factor for the prognosis of HBV-related hepatocellular carcinoma.

BMC cancer - 3 Jun 2026

Quang Trung Pham, Chau Pham, Quang Huy Duong, Xuan Hoan Nghiem, Reboud Julien, Linh Toan Nguyen, Huu Song Le, Tat Trung Ngo

Abstract excerpt

BACKGROUND: Telomerase reverse transcriptase (TERT) promoter mutations are among the most common noncoding genetic lesions in various cancers, including hepatocellular carcinoma (HCC). The clinical and pathological implications of hepatitis B virus (HBV)-related HCC patients carrying promoter mutations are only partially resolved. METHODS: A nested real-time PCR assay was optimized to detect C228T TERT gene...

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Share to Biomarkers, Tumor
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepatitis B

Share to Hepatitis B virus

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 42237300
DOI: 10.1186/s12885-026-16271-0
PMCID: PMC13450528

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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