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Article

Detection of TERT promoter mutation in serum cell-free DNA using wild-type blocking PCR combined with Sanger sequencing in hepatocellular carcinoma.

Journal of medical virology - 1 Dec 2020

Akuta Norio, Suzuki Fumitaka, Kobayashi Mariko, Fujiyama Shunichiro, Kawamura Yusuke, Sezaki Hitomi, Hosaka Tetsuya, Kobayashi Masahiro, Saitoh Satoshi, Arase Yasuji, Ikeda Kenji, Suzuki Yoshiyuki, Kumada Hiromitsu

Abstract excerpt

Telomerase reverse transcriptase (TERT) promoter mutation is the most frequent genetic alteration in hepatocellular carcinoma (HCC). However, there is currently no suitable highly sensitive method that can detect such mutation using serum cell-free DNA (cfDNA). We analyzed somatic point mutations that substitute cytosine for thymidine at position 228 (C228T), as one of the hotspots of TERT promoter mutations, in...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32100879
DOI: 10.1002/jmv.25724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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