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Article

Impact of RUNX1 mutations at distinct sites on the clinical characteristics and prognosis of patients with acute myeloid leukemia.

BMC cancer - 3 Jun 2026

Huang Yun, Long Zhiquan, Zhang Yujiao, Cheng Jiaying, Sun Junya, Jiang Ling, Fu Haipeng, Jiang Xuejie

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) patients with Runt-related transcription factor 1 (RUNX1) mutations are categorized into the adverse-risk group with poor prognosis. However, the impact of RUNX1 mutations at distinct sites on clinical characteristics, chemosensitivity, and prognosis in AML remains incompletely defined. This study aims to elucidate this impact thereby furnishing robust evidence to refine...

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Identifiers

PMID: 42237268
DOI: 10.1186/s12885-026-16238-1
PMCID: PMC13450246

Genes

RUNX1
EFS
RHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group.Semantic proximity Read ↗

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