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Article

Population pharmacokinetics of lumefantrine in pregnant and non-pregnant Nigerian women receiving efavirenz-based antiretroviral therapy.

European journal of clinical pharmacology - 3 Jun 2026

Akinrinade Tawakalt Olamide, Hassan Ibrahim Adebayo, Adegbola Adebanjo Jonathan, Adeleke Adekemi, Nwogu-Attah Jacinta Nwamaka, Eniayewu Oluwasegun, Adehin Ayorinde, Bolaji Oluseye Oladotun

Abstract excerpt

PURPOSE: Lumefantrine is a key partner drug in artemether-lumefantrine therapy, yet data describing its pharmacokinetics among women with efavirenz-based antiretroviral therapy remains limited. This study aimed to characterise the population pharmacokinetics of lumefantrine in pregnant and non-pregnant Nigerians living with HIV, evaluate the influence of pregnancy and CYP3A5 genotype, and assess the adequacy of...

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Alkynes
Anti-HIV Agents
Antimalarials
Benzoxazines
Cyclopropanes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cytochrome P-450 CYP3A

Monte Carlo Method

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PMID: 42234159
DOI: 10.1007/s00228-026-04090-y

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CYP3A5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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