Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women.

Malaria journal - 3 Jul 2017

Mutagonda Ritah F, Kamuhabwa Appolinary A R, Minzi Omary M S, Massawe Siriel N, Asghar Muhammad, Homann Manijeh V, Färnert Anna, Aklillu Eleni

Abstract excerpt

BACKGROUND: Pregnancy has considerable effects on the pharmacokinetic properties of drugs used to treat uncomplicated Plasmodium falciparum malaria. The role of pharmacogenetic variation on anti-malarial drug disposition and efficacy during pregnancy is not well investigated. The study aimed to examine the effect of pharmacogenetics on lumefantrine (LF) pharmacokinetics and treatment outcome in pregnant women....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP2B6
Share to Cytochrome P450 Family 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethanolamines

Share to Fluorenes

Share to Pregnancy Complications, Parasitic

Share to Pregnancy Trimester, Second

Share to Pregnancy Trimester, Third

Share to Steroid Hydroxylases

Source

Open in PubMed Open full text

Identifiers

PMID: 28673292
DOI: 10.1186/s12936-017-1914-9
PMCID: PMC5496343

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women.PMID 28673292Read ↗

Pregnancy and CYP3A5 Genotype Affect Day 7 Plasma Lumefantrine Concentrations.Semantic proximity Read ↗

Influence of selected polymorphisms in disposition genes on lumefantrine pharmacokinetics when coadministered with efavirenz.Semantic proximity Read ↗

Population pharmacokinetics of lumefantrine in pregnant and non-pregnant Nigerian women receiving efavirenz-based antiretroviral therapy.Semantic proximity Read ↗

Burden of malaria in pregnancy in Mali and impact of dosing frequency and antimalarial drug resistance on the effectiveness of intermittent preventive therapy in pregnancy in AfricaSemantic proximity Read ↗

Potential effect of pharmacogenetics on maternal, fetal and infant antiretroviral drug exposure during pregnancy and breastfeeding.Semantic proximity Read ↗

Effect of CYP3A5*3 genotypes on lumefantrine plasma concentrations among malaria-HIV-infected women.Semantic proximity Read ↗

Pharmacogenetics of antimalarial drugs: effect on metabolism and transport.Semantic proximity Read ↗

CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients.Semantic proximity Read ↗

Gestational malaria in Kisangani : Efficacy of Mefloquine vs Sulfadoxine-Pyrimethamine in Intermittent Preventive Treatment : A Study Protocol for a randomized controlled clinical trialSemantic proximity Read ↗

The drug transporter ABCB1 c.3435C>T SNP influences artemether-lumefantrine treatment outcome.Semantic proximity Read ↗

Randomized Trial of Artesunate+Amodiaquine, Sulfadoxine-Pyrimethamine+Amodiaquine, Chlorproguanal-Dapsone and SP for Malaria in Pregnancy in TanzaniaSemantic proximity Read ↗

MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.