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Pregnancy and CYP3A5 Genotype Affect Day 7 Plasma Lumefantrine Concentrations.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2019

Mutagonda Ritah F, Minzi Omary M S, Massawe Siriel N, Asghar Muhammad, Färnert Anna, Kamuhabwa Appolinary A R, Aklillu Eleni

Abstract excerpt

Pregnancy and pharmacogenetics variation alter drug disposition and treatment outcome. The objective of this study was to investigate the effect of pregnancy and pharmacogenetics variation on day 7 lumefantrine (LF) plasma concentration and therapeutic responses in malaria-infected women treated with artemether-lumefantrine (ALu) in Tanzania. A total of 277 (205 pregnant and 72 nonpregnant) women with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Dose-Response Relationship, Drug

Share to Malaria, Falciparum

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Share to Pregnancy Complications, Parasitic

Share to Pregnancy Trimester, Third

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Identifiers

PMID: 31744845
DOI: 10.1124/dmd.119.088062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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