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Article

Influence of selected polymorphisms in disposition genes on lumefantrine pharmacokinetics when coadministered with efavirenz.

Pharmacogenetics and genomics - 1 Jul 2020

Adegbola Adebanjo Jonathan, Rana Abutaima, Adeagbo Babatunde Ayodeji, Bolarinwa Rahman A, Olagunju Adeniyi Ebenezer, Siccardi Marco, Owen Andrew, Bolaji Oluseye Oladotun

Abstract excerpt

BACKGROUND: Coadministration of artemether-lumefantrine and efavirenz has been shown to result in significant interactions. The influence of functional genetic polymorphisms in selected CYPs on the magnitude of this interaction was investigated in pregnant and nonpregnant adults. METHOD: A standard 3-day regimen of artemether-lumefantrine was administered to each patient on steady-state efavirenz-based...

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Identifiers

PMID: 32209837
DOI: 10.1097/FPC.0000000000000401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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