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Article

Noncoding SNP rs17728461 modulates lung cancer progression via interchromosomal regulation of RAB27A expression.

Oncogene - 1 Jul 2026

Jin Yan, Tian Xiaoling, Liu Wenxu, Guo Bing, Lei Xinyue, Liu Xinhua, Li Guoli, Liu Xujing, Xiao Zengtuan, Zhang Mengzhe, Fan Yuxin, Zhang Zhenfa, Ma Zhenyi, Liu Zhe

Abstract excerpt

Genome-wide association studies (GWASs) have revealed the lung cancer susceptibility-associated non-coding SNP rs17728461 C/G. In this study, we demonstrated that rs17728461 is also associated with lung cancer outcome. The risk G allele increases the proliferative index and motility of cancer cells and promotes cancer metastasis in vivo in a xenograft mouse model. Mechanistically, rs17728461-G establishes a...

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Share to Cell Line, Tumor
Share to Cell Proliferation
Share to Disease Progression
Share to Gene Expression Regulation, Neoplastic
Share to Genome-Wide Association Study
Share to Lung Neoplasms
Share to Quantitative Trait Loci
Share to rab27 GTP-Binding Proteins

Source

Identifiers

PMID: 42230797
DOI: 10.1038/s41388-026-03834-5

Genes

RAB27A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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