Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients.

BMC genomics - 1 Jan 2014

Mah Tzia Liang, Yap Xin Ning Adeline, Limviphuvadh Vachiranee, Li Nanpu, Sridharan Srinath, Kuralmani Vellaisemy, Feng Mengling, Liem Natalia, Adhikari Sharmila, Yong Wei Peng, Soo Ross A, Maurer-Stroh Sebastian, Eisenhaber Frank, Tong Joo Chuan

Abstract excerpt

BACKGROUND: Non-small cell lung cancer (NSCLC) is a major cause of cancer-related death worldwide due to poor patient prognosis and clinical outcome. Here, we studied the genetic variations underlying NSCLC pathogenesis based on their association to patient outcome after gemcitabine therapy. RESULTS: Bioinformatics analysis was used to investigate possible effects of POLA2 G583R (POLA2+1747 GG/GA, dbSNP ID:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Nucleus

Share to Computational Biology

Share to Deoxycytidine

Share to DNA Polymerase I

Share to Gemcitabine

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 25521664
DOI: 10.1186/1471-2164-15-S9-S20
PMCID: PMC4290611

Genes

POLA2

Variants

rs487989

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients.PMID 25521664Read ↗

Knockdown of POLA2 increases gemcitabine resistance in lung cancer cells.Semantic proximity Read ↗

Whole-exome sequencing analysis of NSCLC reveals the pathogenic missense variants from cancer-associated genes.Semantic proximity Read ↗

Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy.Semantic proximity Read ↗

Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.Semantic proximity Read ↗

Identification of Molecular Biomarkers Associated with Non-Small-Cell Lung Carcinoma (NSCLC) Using Whole-Exome Sequencing AnalysisSemantic proximity Read ↗

Platinum Drug Sensitivity Polymorphisms in Stage III Non-small Cell Lung Cancer With Invasion of Mediastinal Lymph Nodes.Semantic proximity Read ↗

Potentially functional genetic variants in PLIN2, SULT2A1 and UGT1A9 genes of the ketone pathway and survival of nonsmall cell lung cancer.Semantic proximity Read ↗

Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencingSemantic proximity Read ↗

Potentially functional polymorphisms in DNA repair genes and non-small-cell lung cancer survival: a pathway-based analysis.Semantic proximity Read ↗

DNA Repair Gene Polymorphisms in Relation to Non-Small Cell Lung Cancer Survival.Semantic proximity Read ↗

Gemcitabine metabolic pathway genetic polymorphisms and response in patients with non-small cell lung cancer.Semantic proximity Read ↗

Advances in Targeted Therapy and Immunotherapy for Non-small Cell Lung Cancer Based on Accurate Molecular TypingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.