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Article

Identification of immune-mediated aging genes associated with cervical spondylosis through single-cell eQTL Mendelian randomization.

Frontiers in immunology - 1 Jan 2026

Liu Zuozhong, Xu Haitao

Abstract excerpt

Background: Cervical spondylosis (CS) is an age-related degenerative spinal disorder with increasing evidence linking its pathogenesis to immune aging. The genetic mechanisms connecting immune dysregulation to CS remain largely undefined. Methods: We integrated GWAS data from 484,598 individuals with single-cell eQTL profiles across 14 immune cell types, using Mendelian randomization (MR) and Bayesian...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41789069
DOI: 10.3389/fimmu.2026.1766215
PMCID: PMC12956539

Genes

CS
BMPR2
CD4
CHUK
CTNNB1
CTSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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