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From biochemical markers to molecular endotypes of osteoarthritis: a review on validated biomarkers.

Expert review of molecular diagnostics - 1 Jan 2024

Hannani Monica T, Thudium Christian S, Karsdal Morten A, Ladel Christoph, Mobasheri Ali, Uebelhoer Melanie, Larkin Jonathan, Bacardit Jaume, Struglics André, Bay-Jensen Anne-Christine

Abstract excerpt

INTRODUCTION: Osteoarthritis (OA) affects over 500 million people worldwide. OA patients are symptomatically treated, and current therapies exhibit marginal efficacy and frequently carry safety-risks associated with chronic use. No disease-modifying therapies have been approved to date leaving surgical joint replacement as a last resort. To enable effective patient care and successful drug development there is an...

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PMID: 38353446
DOI: 10.1080/14737159.2024.2315282

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