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Article

Genetic background of obesity: a case-control study.

Hormones (Athens, Greece) - 1 Jun 2026

Kalesis Konstantinos, Roidοs Paris, Nikolopoulos Vaios, Katsiki Niki, Kotsa Kalliopi, Koufakis Theoharis

Abstract excerpt

PURPOSE: The rising prevalence of obesity and type 2 diabetes mellitus (T2DM) constitutes a major global public health concern. Increasing evidence indicates that genetic polymorphisms may modulate the risk of T2DM in individuals with obesity, providing valuable insight into the biological pathways that connect these interrelated disorders. A better understanding of the genetic determinants underlying...

Read the complete abstract on PubMed

Topics

Humans
Case-Control Studies
Transcription Factor 7-Like 2 Protein
Diabetes Mellitus, Type 2
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Obesity

Male

PPAR gamma

Genetic Predisposition to Disease

Middle Aged

Polymorphism, Single Nucleotide

Greece

Adult

Aged

Risk Factors

Gene Frequency

Odds Ratio

Source

Open in PubMed Open full text

Identifiers

PMID: 42230483
DOI: 10.1007/s42000-026-00790-3
PMCID: PMC13582106

Genes

FTO
TCF7L2
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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