Article
Characterization and activity enhancement of a novel thermostable 3-quinuclidinone reductase through modulating the microenvironment of catalytic residues.
Bioresource technology - 1 Oct 2026
Lou Deshuai, Duan Jingfa, Zhou Bingpu, Zhou Huanyu, Wang Yue, Yang Junjiao, Cui Jinghao, Ma Xiaohui, Tan Jun, Duan Hongtao
Abstract excerpt
The biocatalytic synthesis of chiral alcohols offers a sustainable alternative to traditional chemical catalysis, yet the lack of robust, high-efficiency enzymes remains an industrial bottleneck. Here, a novel thermostable 3-quinuclidinone reductase (SdQR) was discovered via metagenomic mining of hot spring environments and biochemically characterized. Among the candidates, the H161Q variant, situated proximal to...
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