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Article

Genomic informational field theory to identify genetic associations of a complex trait using a small sample size.

Physiological genomics - 1 Jul 2026

Kyratzi Panagiota, Gadsby Scott, Knowles Edd, Harris Patricia, Menzies-Gow Nicola, Elliott Jonathan, Paldi Andras, Wattis Jonathan, Rauch Cyril

Abstract excerpt

Genome-wide association studies (GWASs) are commonly used to investigate the genetic basis of complex traits. However, to be adequately powered, they typically require large sample sizes to provide precise inferences. To address this challenge, this article introduces genomic informational field theory (GIFT), a novel data-analytic method that enhances the power of genetic analyses, enabling the use of smaller...

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PMID: 42227876
DOI: 10.1152/physiolgenomics.00205.2025

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